Artificial intelligence may excel at answering questions, but can it help identify which ones to ask? Drawing on their previously published research, John Garry (Queen’s University Belfast), Mark Tomlinson (Stellenbosch University), and Maria Lohan (Queen’s Belfast) consider how AI tools like ChatGPT could assist with setting priority research agendas and questions in health research by analyzing large datasets and synthesizing perspectives. While they note AI’s potential benefits in terms of increasing research efficiency and scope, the authors also discuss potential risks of AI use, such as lack of methodological transparency and stakeholder alienation. Ultimately, Garry, Tomlinson, and Lohan posit that alongside AI adoption, human engagement remains crucial for ensuring legitimacy and adoption of research priorities in health research.