Higher education must undergo a profound transformation to meet the challenges and opportunities posed by artificial intelligence (AI), write Teruo Fujii (University of Tokyo) and Joseph E Aoun (Northeastern University). Fujii and Aoun assert that higher education must instill a passion for innovation and interdisciplinary learning among its students, foster partnerships with the private sector, encourage more opportunities for experiential learning, and prepare students to be lifelong learners and adaptable thinkers. “By embracing these principles, universities can not only survive, but can also thrive in the age of AI, contributing to the development of skilled and adaptable talent that can navigate the complexities of our evolving world,” they conclude.